People with Down syndrome have irregular posterior corneal surfaces

People with Down syndrome have irregular posterior corneal surfaces


Comprehensive Ophthalmology, Cornea/External Disease, Refractive Mgmt/Intervention


This analysis characterizes posterior corneal surface features in patients with Down syndrome.

Study design

This retrospective, comparative, nonrandomized, clinical study comprised 123 eyes divided into 3 groups: 37 eyes of patients with Down Syndrome (mean age 24 years), 46 with mild keratoconus (mean age 38 years) and 40 healthy controls (mean age 37.7 years).

Outcomes

Patients with Down syndrome had steeper posterior corneal curvatures and more higher-order aberrations compared with healthy controls, but was statistically similar to the mild keratoconus group.

Limitations

This study was limited by the absence of age matching between groups.

Clinical significance

The posterior corneal surface of patients with Down syndrome exhibits similarities to patients with early keratoconus. It is possible that Down Syndrome patients are affected by a specific keratopathy, which requires further study.