Conjunctival actinic granuloma may be associated with allergy and atopy

Conjunctival actinic granuloma may be associated with allergy and atopy


Cornea/External Disease


This retrospective, observational, series study looked for cases of actinic granuloma of the conjunctiva in patient records covering a 6-year period to discover its clinical manifestations and histopathologic features.

Study design

Institutional pathology records between 2014 and 2020 were searched for all cases of conjunctival actinic granuloma. Eight eyes of 8 patients were identified.

Outcomes

Histopathologically, actinic granuloma was associated with pterygium (n = 6, 75%) and pinguecula (n = 2, 25%). All lesions comprised predominantly histiocytes and a variable number of foreign body–type giant cells associated with a focus of severe actinic elastosis. The inflammatory pattern was giant cell (n = 4, 50%), sarcoidal (n = 2, 25%), histiocytic (n = 1, 13%), and combined histiocytic and sarcoidal (n = 1, 13%).

Limitations

None.

Clinical significance

Conjunctival actinic granuloma has diverse clinical and histopathologic manifestations, which need to be distinguished from other autoimmune, neoplastic, and infectious etiologies. This lesion frequently occurs in pre-existing pterygium and pinguecula and may be associated with allergy and atopy.

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